業績


論文2020年

  1. Ayako Hoshi, Nobuhiro Nagai, Reiko Daigaku, Remi Motoyama, Saaya Saijo, Hirokazu Kaji, Toshiaki Abe. “Effect of sustained insulin releasing device made of poly(ethyleneglycol) dimethacrylates on retinal function in streptozotocin-induced diabetic ratsJournal of Materials Science: Materials in Medicine, 31, 52 (2020).
  2. Hideto Kojima, Bibek Raut, Li-Jiun Chen, Nobuhiro Nagai, Toshiaki Abe, Hirokazu Kaji. “A 3D printed self-sustainable cell-encapsulation drug delivery device for periocular transplant-based treatment of retinal degenerative diseasesMicromachines, 11(4), E436 (2020).
  3. Li-Jiun Chen, Bibek Raut, Nobuhiro Nagai, Toshiaki Abe, Hirokazu Kaji. “Prototyping a versatile two-layer multi-channel microfluidic device for direct cell-vessel co-cultureMicromachines, 11(1), E79 (2020).


論文2019年

  1. Nobuhiro Nagai, Hirokazu Kaji, Toshiaki Abe “Development of transscleral sustained drug release device aimed at treatment of intractable retinal diseaseImpact, 3, 47-49 (2019).
  2. Nobuhiro Nagai, Saaya Saijo, Yuanhui Song, Hirokazu Kaji, Toshiaki Abe. “A drug refillable device for transscleral sustained drug delivery to the retinaEuropean Journal of Pharmaceutics and Biopharmaceutics, 136, 184-191 (2019).
  3. Yuto Sato, Nobuhiro Nagai, Toshiaki Abe, Hirokazu Kaji. “A multilayered sheet-type device capable of sustained drug release and deployment controlBiomedical Microdevices, 21(3), 60 (2019).
  4. Nobuhiro Nagai, Zhaleh Kashkouli Nezhad, Reiko Daigaku, Yuanhui Song, Saaya Saijo, Keiko Terata, Ayako Hoshi, Matsuhiko Nishizawa, Toru Nakazawa, Hirokazu Kaji, Toshiaki Abe. “Transscleral sustained ranibizumab delivery using an episcleral implantable device: Suppression of laser-induced choroidal neovascularization in ratsInternational Journal of Pharmaceutics, 567, 118458 (2019).


論文2018年

  1. Yuanhui Song, Nobuhiro Nagai, Saaya Saijo, Hirokazu Kaji, Matsuhiko Nishizawa, Toshiaki Abe “In situ forming injectable chitosan-gelatin hydrogels for sustained intraocular drug delivery through double crosslinking strategy” Materials Science & Engineering C, 88, 1-12 (2018).
  2. Nobuhiro Nagai, Shinji Yamada, Junichi Kawasaki, Eri Koyanagi, Saaya Saijo, Hirokazu Kaji, Matsuhiko Nishizawa, Toru Nakazawa, Toshiaki Abe. “Pharmacokinetic and Safety Evaluation of a Transscleral Sustained Unoprostone Release Device in Monkey Eyes” Investigative Ophthalmology & Visual Science, 59(2), 644-652 (2018).
  3. Taro Kondo, Zhaleh Kashkouli Nezhad, Jin Suzuki, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji. “A self-deploying drug release device using polymeric films” Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106(2), 780-786 (2018).
  4. Koji M Nishiguchi1, Yu Yokoyama, Hiroshi Kunikata, Toshiaki Abe, Toru Nakazawa. “Correlation between aqueous flare and residual visual field area in retinitis pigmentosa” British Journal of Ophthalmology, doi: 10.1136/bjophthalmol-2018-312225 (2018).
  5. Hirokazu Kaji, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe. “Drug delivery devices for retinal diseases” Advanced Drug Delivery Reviews, 128, 148-157 (2018).
  6. Yuto Sato, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji “Development of a multilayered drug-delivery sheet that allows minimally invasive delivery to the eye” EMBS Micro and Nanotechnology in Medicine Conference (MNMC 2018), Meeting Abstracts (2018).
  7. Hideto Kojima, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji “Development of an implantable cell culture device for retinal diseases” EMBS Micro and Nanotechnology in Medicine Conference (MNMC 2018), Meeting Abstracts (2018).
  8. Shun Ito, Li-Jiun Chen, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji “Microfluidic cell culture model of the outer-blood-retinal-barrier” EMBS Micro and Nanotechnology in Medicine Conference (MNMC 2018), Meeting Abstracts (2018).
  9. Nobuhiro Nagai, Saaya Saijo, Yuanhui Song, Hirokazu Kaji, Matsuhiko Nishizawa, Toshiaki Abe “A Refillable Drug Delivery Device to the Retina” Investigative Ophthalmology & Visual Science, 59(9), 5704 (2018).


論文2017年

  1. Shinji Yamada, Nobuhiro Nagai, Saaya Saijo, Hirokazu Kaji, Kozue Imura, Masafumi Goto, Toshiaki Abe. “Controlled basic fibroblast growth factor release device made of poly(ethyleneglycol) dimethacrylates for creating a subcutaneous neovascular bed for cell transplantation” Journal of Biomedical Materials Research Part A, 105(11), 3017-3024 (2017).
  2. Li-Jiun Chen, Shuntaro Ito, Hiroyuki Kai, Kuniaki Nagamine, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji. “Microfluidic co-cultures of retinal pigment epithelial cells and vascular endothelial cells to investigate choroidal angiogenesis” Scientific Reports, 7(1):3538 (2017).
  3. Nobuhiro Nagai, Yasuko Izumida, Yoshimasa Yamazaki, Hirokazu Kaji, Junichi Kawasaki, Matsuhiko Nishizawa, Toshiaki Abe. “Physicochemical and biological characterization of sustained isopropyl unoprostone-release device made of poly(ethyleneglycol) dimethacrylates” Journal of Materials Science: Materials in Medicine, 28(107), 1-7 (2017).
  4. Jin Suzuki, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji. “Electrochemical Manipulation of Cell Populations Supported by Biodegradable Polymeric Nanosheets for Cell Transplantation Therapy” Biomaterials Science, 5(2), 216-222 (2017).
  5. Toshiaki Abe, Aya Katsuyama, Shinji Yamada, Nobuhiro Nagai, Reiko Daigaku, Kenta Ishida, Yuki Katsukura “Non-histone nuclear protein play important roles for photoreceptor function and experimental choroidal neovascularization” Investigative Ophthalmology & Visual Science, 58(8), 5228 (2017).
  6. Nobuhiro Nagai, Zhaleh Kashikouli Nezhad, Saaya Saijo, Hirokazu Kaji, Matsuhiko Nishizawa, Toru Nakazawa, Toshiaki Abe “Biodegradable injectable sheet as transscleral drug delivery system” Investigative Ophthalmology & Visual Science, 58 (8), 4464 (2017).


論文2016年

  1. Nobuhiro Nagai, Eri Koyanagi, Yasuko Izumida, Junjun Liu, Aya Katsuyama, Hirokazu Kaji, Matsuhiko Nishizawa, Noriko Osumi, Mineo Kondo, Hiroko Terasaki, Yukihiko Mashima, Toru Nakazawa, Toshiaki Abe. “Long-term Protection of Genetically-Ablated Rabbit Retinal Degeneration by Sustained Transscleral Unoprostone Delivery” Investigative Ophthalmology & Visual Science, 57(15), 6527-6538 (2016).
  2. Nobuhiro Nagai, Hirokazu Kaji, Matsuhiko Nishizawa, Toru Nakazawa, Toshiaki Abe. “Transscleral controlled delivery of geranylgeranylaceton using a polymeric device protects rat retina against light injury” Advances in Experimental Medicine and Biology, 854, 471-477 (2016).
  3. Nobuhiro Nagai, Satoru Iwata, Kaori Sampei, Hideyuki Onami, Hirokazu Kaji, Matsuhiko Nishizawa, Toru Nakazawa, Yukihiko Mashima, Toshiaki Abe. “Protective effects of transscleral sustained unoprostone delivery against retinal degeneration in S334ter rhodopsin mutant rats” Journal of Biomedical Materials Research Part B: Applied Biomaterials, 104(8), 1730-1737 (2016).
  4. Hiroshi Kunikata, Toshiaki Abe, Toru Nakazawa. “Heads-Up Macular Surgery with a 27-Gauge Microincision Vitrectomy System and Minimal Illumination” Case Reports in Ophthalmology, 7, 265–269 (2016).
  5. Toshiaki Abe, Yasuko Izumida, Hirokazu Kaji, Matsuhiko Nishizawa, Yukihiko Mashima, Toru Nakazawa, Nobuhiro Nagai “Characterization of a novel drug releasing device for retinal diseases” RD2016 XVIIth International Symposium on Retinal Degenerations, Meeting Abstracts (2016).
  6. Jin Suzuki, Taro Kondo, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji “Electrochemical Manipulation of Living Cells Supported By Polymeric Nanosheets” The Electrochemical Society, Meeting Abstracts, 53, 3967 (2016).
  7. Taro Kondo, Zhaleh Kashikouli Nezhad, Jin Suzuki, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji “Drug Delivery System Using Injectable Polymeric Sheets” The Electrochemical Society, Meeting Abstracts, 54, 4122 (2016).
  8. Li Jiun Chen, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji “In Vitro Angiogenesis: Co-Culture Model of the Retina in Microfluidic Devices” The Electrochemical Society, Meeting Abstracts, 51, 3840 (2016).
  9. Nobuhiro Nagai, Yasuko Izumida, Hirokazu Kaji, Matsuhiko Nishizawa, Aya Katsuyama, Shinji Yamada, Toru Nakazawa, Mineo Kondo, Hiroko Terasaki, Yukihiko Mashima, Toshiaki Abe “Protective Effects of Sustained Unoprostone Release Device in Rhodopsin Pro347Leu Transgenic Rabbits” Investigative Ophthalmology & Visual Science, 57 (12), 4017 (2016).
  10. Toshiaki Abe, Aya Katsuyama, Shinji Yamada, Yuki Katsukura, Zhaleh Kashkouli Nezhad, Nobuhiro Nagai “A non-histone nuclear protein enhances VEGF expression and choroidal neovascularization” Investigative Ophthalmology & Visual Science, 57 (12), 5793 (2016).


論文2015年

  1. Zhaleh Kashkouli Nezhad, Nobuhiro Nagai, Kotaro Yamamoto, Hirokazu Kaji, Matsuhiko Nishizawa, Hideyuki Saya, Toru Nakazawa, Toshiaki Abe. “Application of clotrimazole via a novel controlled release device provides potent retinal neuroprotection” Journal of Materials Science: Materials in Medicine, 26(9):230, 1-8 (2015).
  2. Nobuhiro Nagai, Yasuko Izumida, Remi Motoyama, Eri Koyanagi, Aya Katsuyama, Shinji Yamada, Hirokazu Kaji, Matsuhiko Nishizawa, Toshiaki Abe “Polymeric device based on UV-cured poly(ethyleneglycol) dimethacrylates for controlled intraocular drug delivery” Pacifichem2015, Meeting abstract (2015).
  3. Shinji Yamada, Nobuhiro Nagai, Hirokazu Kaji, Aya Katsuyama, Matsuhiko Nishizawa, Toshiaki Abe “Controlled drug release device fabricated with PDMS mold-based UV curing of polyethyleneglycol dimethacrylates” BMES 2015 annual meeting, Meeting abstract (2015).
  4. Toshiaki Abe, Shinji Yamada, Hirokazu Kaji, Aya Katsuyama, Matsuhiko Nishizawa, Nobuhiro Nagai “Sustained release system of ranibizumab for transscleral administration” BMES 2015 annual meeting, Meeting abstract (2015). (2015)
  5. Hirokazu Kaji, Taro Kondo, Nobuhiro Nagai, Toshiaki Abe “Injectable Ultrathin Polymeric Films for Subretinal Cell Delivery” BMES 2015 annual meeting (2015).
  6. Hirokazu Kaji, Taro Kondo, Yoshihiro Mori, Nobuhiro Nagai, Toshiaki Abe “Injectable Polymeric Nanosheets for Subretinal Cell Delivery” TISSUE ENGINEERING PART A, 21, S276-S276 (2015).
  7. Nobuhiro Nagai, Yasuko Izumida, Eri Koyanagi, Hirokazu Kaji, Matsuhiko Nishizawa, Takahito Imagawa, Akiko Morikawa, Toru Nakazawa, Yukihiko Mashima, Toshiaki Abe “Pharmacokinetic and Safety Evaluation of a Transscleral Sustained Unoprostone Release Device” Investigative Ophthalmology & Visual Science, 56 (7), 4153-4153 (2015).
  8. Toshiaki Abe, Aya Katsuyama, Hideyuki Onami, Toru Nakazawa, Nobuhiro Nagai “Transscleral Sustained Ranibizumab Delivery Device Using Polyethyleneglycol Dimethacrylates” Investigative Ophthalmology & Visual Science, 56 (7), 4146-4146 (2015).
  9. Nobuhiro Nagai, Hirokazu Kaji, Matsuhiko Nishizawa, Toru Nakazawa, Toshiaki Abe “Episclera Implantable Device fabricated with PDMS mold-based UV curing” BIT’s 1st Annual World Congress of Smart Materials 2015, Meeting abstract (2015).
  10. Toshiaki Abe, Hirokazu Kaji, Matsuhiko Nishizawa, Toru Nakazawa, Yukihiko Mashima, Nobuhiro Nagai “Polymeric Device for Transscleral Multi-drug Delivery” BIT’s 1st Annual World Congress of Smart Materials 2015, Meeting abstract (2015).
  11. Aya Katsuyama, Nobuhiro Nagai, Hideyuki Onami, Toru Nakazawa, Toshiaki Abe “Fabrication of a Capsule Device using Polyethyleneglycol Dimethacrylates for Extended Release of Ranibizumab” BIT’s 1st Annual World Congress of Smart Materials 2015, Meeting abstract (2015).
  12. Nobuhiro Nagai “Polymeric device for transscleral drug delivery to the posterior segment” Asia-Arvo 2015, Meeting abstract (2015).


論文2014年

  1. Toshiaki Abe, Nobuhiro Nagai. “Neuroprotection for photoreceptors” Neuroprotection and Neuroregeneration for Retinal Diseases, 191-204 (2014).
  2. Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Yuki Katsukura, Yumi Ishikawa, Zhaleh Kashkouli Nezhad, Kaori Sampei, Satoru Iwata, Shuntaro Ito, Matsuhiko Nishizawa, Toru Nakazawa, Noriko Osumi, Yukihiko Mashima, Toshiaki Abe. “A platform for controlled dual-drug delivery to the retina: protective effects against light-induced retinal damage in rats” Advanced Healthcare Materials, 3(10), 1555-1560 (2014).  
  3. Joshua O. Eniwumide, Masaru Tanaka, Nobuhiro Nagai, Yuka Morita, Joost de Bruijn, Sadaaki Yamamoto, Shin Onodera, Eiji Kondo, Kazunori Yasuda, Masatsugu Shimomura. “The morphology and functions of articular chondrocytes on a honeycomb-patterned surface” BioMed Research International, Article ID 710354 (2014).
  4. Toshiaki Abe, Yumi Tokita-Ishikawa, Hideyuki Onami, Yuki Katsukura, Hirokazu Kaji, Matsuhiko Nishizawa, Nobuhiro Nagai. “Intrascleral transplantation of a collagen sheet with cultured brain-derived neurotrophic factor expressing cells partially rescues the retina from damage due to acute high intraocular pressure” Advances in Experimental Medicine and Biology, 801, 837-843 (2014).
  5. Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Yumi Ishikawa, Matsuhiko Nishizawa, Noriko Osumi, Toru Nakazawa, Toshiaki Abe. “A polymeric device for controlled transscleral multi-drug delivery to the posterior segment of the eye” Acta Biomaterialia, 10, 680-687 (2014).).
  6. Toshinori Fujie, Yoshihiro Mori, Shuntaro Ito, Matsuhiko Nishizawa, Hojae Bae, Nobuhiro Nagai, Hideyuki Onami, Toshiaki Abe, Ali Khademhosseini, Hirokazu Kaji. “Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer” Advanced Materials, 26(11), 1699-1705 (2014).
  7. Wataru Kobayashi, Hiroshi Kunikata, Toshiaki Abe, Toru Nakazawa. ”Retrospective Comparison of 25- and 23-Gauge Microincision Vitrectomy Surgery and 20-Gauge Vitrectomy for the Repair of Macular Hole Retinal Detachment” Asia-Pacific Journal of Ophthalmology, 3(6), 331-336 (2014).
  8. Noriyuki Suzuki, Hiroshi Kunikata, Naoko Aizawa, Toshiaki Abe, Toru Nakazawa. “Predicting Visual Outcomes for Macula-Off Rhegmatogenous Retinal Detachment with Optical Coherence Tomography” Journal of Ophthalmology, ID 269837 (2014).
  9. Hiroshi Kunikata, Naoko Aizawa, Nobuo Fuse, Toshiaki Abe, Toru Nakazawa. “25-Gauge Microincision Vitrectomy to Treat Vitreoretinal Disease in Glaucomatous Eyes after Trabeculectomy” Journal of Ophthalmology, ID 306814 (2014).
  10. Hirokazu Kaji, Yoshinori Fujie, Yoshihiro Mori, Nobuhiro Nagai, Khademhosseini Ali, Toshiaki Abe “Cell delivery system using micropatterned polymeric nanosheets” Society for biomaterials, 2014 annual meeting, Meeting abstract (2014).
  11. Nobuhiro Nagai, Hirokazu Kaji, Zhaleh Kashkouli Nezhad, Kaori Sampei, Satoru Iwata, Matsuhiko Nishizawa, Yukihiko Mashima, Toshiaki Abe “Controlled Transscleral Dual-drug Delivery by a Polymeric Device Reduces Light-induced Retinal Damage” Investigative Ophthalmology & Visual Science, 55 (13), 446-446 (2014).
  12. Zhaleh Kashkouli Nezhad, Nobuhiro Nagai, Kotaro Yamamoto, Hideyuki Saya, Toru Nakazawa, Toshiaki Abe “Sustained clotrimazole release attenuates light-induced retinal damage through modulation of reactive oxygen species (ROS) and mitogen-activated protein kinases (MAPKs)” Investigative Ophthalmology & Visual Science, 55 (13), 483-483 (2014).
  13. Hirokazu Kaji, Toshinori Fujie, Nobuhiro Nagai, Toshiaki Abe “Local Delivery of an Engineered Epithelial Monolayer by Micropatterned Polymeric Nanosheets” Investigative Ophthalmology & Visual Science, 55 (13), 1449-1449 (2014).
  14. Toshinori Fujie, Yoshihiro Mori, Matsuhiko Nishizawa, Nobuhiro Nagai, Toshiaki Abe, Ali Khademhosseini, Hirokazu Kaji “Micropatterned polymeric nanosheets for local injection of an engineered epithelial monolayer” ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 248 (2014).


論文2013年

  1. Hiroyuki Mori, Eiji Kondo, Yasuyuki Kawaguchi, Nobuto Kitamura, Nobuhiro Nagai, Hirokazu Iida, Kazunori Yasuda. “Development of a salmon-derived crosslinked atelocollagen sponge disc containing osteogenic protein-1 for articular cartilage regeneration: in vivo evaluations with rabbits” BMC Musculoskeletal Disorders, 14(1), 174 (2013).
  2. Hideyuki Onami, Nobuhiro Nagai, Hirokazu Kaji, Matsuhiko Nishizawa, Yasufumi Sato, Noriko Osumi, Toru Nakazawa, Toshiaki Abe. “Transscleral sustained vasohibin-1 delivery by a novel device suppressed experimentally induced choroidal neovascularization” PLoS ONE, 8(3), e58580, (2013).
  3. Kunikata H, Yasuda M, Aizawa N, Tanaka Y, Abe T, Nakazawa T. „Intraocular concentrations of cytokines and chemokines in rhegmatogenous retinal detachment and the effect of intravitreal triamcinolone acetonide“ Am J Ophthalmol, 155(6): 1028-1037 (2013).
  4. Kunikata H, Aizawa N, Meguro Y, Abe T, Nakazawa T. “Combined 25-gauge microincision vitrectomy and toric intraocular lens implantation with posterior capsulotomy“ Ophthalmic Surg Lasers Imaging Retina, 44(2): 145-154 (2013).
  5. Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Takuya Yamada, Yuki Katsukura, Yumi Ishikawa, Matsuhiko Nishizawa, Yukihiko Mashima, Toshiaki Abe “Protective Effects of Transscleral Drug Delivery Device Against Photoreceptor Cell Death in S334ter Rhodopsin Mutant Rats” Investigative Ophthalmology & Visual Science, 54 (15), 5064-5064 (2013).


論文2012年

  1. Hideyuki Onami, Nobuhiro Nagai, Shigeki Machida, Norihiro Kumasaka, Ryosuke Wakusawa, Yumi Ishikawa, Hikaru Sonoda, Yasufumi Sato, Toshiaki Abe. “Reduction of laser-induced choroidal neovascularization by intravitreal vasohibin-1 in monkey eyes” RETINA The Journal of Retinal and Vitreous Diseases, 32(6), 1204-1213 (2012).
  2. Yumi Ishikawa, Nobuhiro Nagai, Hideyuki Onami, Norihiro Kumasaka, Ryosuke Wakusawa, Hikaru Sonoda, Yasufumi Sato, Toshiaki Abe. “Vasohibin-1 and retinal pigment epithelium” Advances in Experimental Medicine and Biology, 723, 305-310 (2012).
  3. Kobayashi W, Abe T, Tamai H, Nakazawa T. “Choroidal excavation with polypoidal choroidal vasculopathy: a case report” Clin Ophthalmol, 6, 1373-6 (2012).
  4. Shanab AY, Nakazawa T, Ryu M, Tanaka Y, Himori N, Taguchi K, Yasuda M, Watanabe R, Takano J, Saido T, Minegishi N, Miyata T, Abe T, Yamamoto M. “Metabolic stress response implicated in diabetic retinopathy: the role of calpain, and the therapeutic impact of calpain inhibitor” Neurobiol Dis, 48(3), 556-67 (2012).
  5. Aizawa N, Kunikata H, Abe T, Nakazawa T. “Efficacy of combined 25-gauge microincision vitrectomy, intraocular lens implantation, and posterior capsulotomy” J Cataract Refract Surg, 38(9), 1602-7 (2012).
  6. Hirokazu Kaji, Nobuhiro Nagai, Takuya Yamada, Matsuhiko Nishizawa, Toshiaki Abe “An implantable drug delivery device for treating retinal disorders” IEEE-EMBS Micro- and Nanoengineering in Medicine Conference, Meeting abstract (2012).
  7. Hirokazu Kaji, Nobuhiro Nagai, Takuya Yamada, Matsuhiko Nishizawa, Toshiaki Abe “A controlled-release capsule device for transscleral drug delivery to the retina” Proceedings of μTAS 2012 Conference, Meeting abstract (2012).
  8. Hirokazu Kaji, Syuntaro Ito, Nobuhiro Nagai, Kuniaki Nagamine, Matsuhiko Nishizawa, Toshiaki Abe “Development of a cell-based model of the retina within a microfluidic device” Symposium on New Technology for Cell-based Drug Assay, Meeting abstract (2012).
  9. Toshiaki Abe, Yumi Ishikawa, Hideyuki Onami, Yuki Katsukura, Nobuhiro Nagai “Intra-scleral transplantation of collagen sheet with cultured brain-derived neurotrophic factor expressing cells partially rescued the retina from the damage of acute high intraocular pressure” RD2012 XV International Symposium on Retinal Degeneration, Meeting abstract (2012).
  10. Nobuhiro Nagai, Hideyuki Onami, Hirokazu Kaji, Takuya Yamada, Yuki Katsukura, Machiko Sato, Yumi Ishikawa, Toru Nakazawa, Matsuhiko Nishizawa, and Toshiaki Abe “Protective Effects of Transscleral Drug Delivery Device Against Light-induced Retinal Damage in Rats” Investigative Ophthalmology & Visual Science, 53 (14), 470-470 (2012).
  11. Hideyuki Onami, Nobuhiro Nagai, Ryosuke Wakusawa , Hirokazu Kaji, Takuya Yamada, Yumi Ishikawa, Matsuhiko Nishizawa, Yasufumi Sato, Toru Nakazawa,and Toshiaki Abe “Suppression of Rat Choroidal Neovascularization by Transscleral Vasohibin-1 Delivery Device” Investigative Ophthalmology & Visual Science, 53 (14), 475-475 (2012).


論文2011年

  1. Takeo Miyake, Keigo Haneda, Nobuhiro Nagai, Yohei Yatagawa, Hideyuki Onami, Syuhei Yoshino, Toshiaki Abe, Matsuhiko Nishizawa. “Enzymatic biofuel cells designed for direct power generation from biofluids in living organisms” Energy & Environmental Science, 4, 5008-5012 (2011).
  2. Nobuhiro Nagai, Ryosuke Kubota, Ryohei Okahashi, Masanobu Munekata. “Mechanical and biological properties of bio-inspired nano-fibrous elastic materials from collagen” Biomaterials – Physics and Chemistry edited by Rosario Pignatello. Intech (Book chapter), chapter 13, 259-274 (2011).
  3. Ryosuke Wakusawa, Toshiaki Abe, Hajime Sato, Hikaru Sonoda, Masaaki Sato, Yuuichi Mitsuda, Tomoaki Takakura, Tomi Fukushima, Hideyuki Onami, Nobuhiro Nagai, Yumi Ishikawa, Kohji Nishida, Yasufumi Sato. “Suppression of choroidal neovascularization by vasohibin-1, a vascular endothelium-derived angiogenic inhibitor” Investigative Ophthalmology & Visual Science, 52(6), 3272-3280 (2011).
  4. Yasuyuki Kawaguchi, Eiji Kondo, Nobuto Kitamura, Kazunobu Arakaki, Yasuhito Tanaka, Masanobu Munekata, Nobuhiro Nagai, Kazunori Yasuda. “In vivo effects of isolated implantation of salmon-derived crosslinked atelocollagen sponge into an osteochondral defect” Journal of Materials Science: Materials in Medicine, 22(2), 397-404 (2011).
  5. Takeaki Kawashima, Nobuhiro Nagai, Hirokazu Kaji, Norihiro Kumasaka, Hideyuki Onami, Yumi Ishikawa, Noriko Osumi, Matsuhiko Nishizawa, Toshiaki Abe. “A scalable controlled-release device for transscleral drug delivery to the retina” Biomaterials, 32(7), 1950-1956 (2011).
  6. Kunikata H, Abe T, Nishida K. “Successful outcomes of 25- and 23-gauge vitrectomies for giant retinal tear detachments” Ophthalmic Surg Lasers Imaging, 42(6), 487-92 (2011).
  7. Kunikata H, Nitta F, Meguro Y, Aizawa N, Hariya T, Chiba N, Abe T, Nishida K. “Difficulty in inserting 25- and 23-gauge trocar cannula during vitrectomy” Ophthalmologica, 226(4), 198-204 (2011).
  8. Kunikata H, Fuse N, Abe T. “Fixating dislocated intraocular lens by 25-gauge vitrectomy” Ophthalmic Surg Lasers Imaging, 42(4), 297-301 (2011).
  9. Kunikata H, Abe T, Kinukawa J, Nishida K. “Preoperative factors predictive of postoperative decimal visual acuity > 1.0 following surgical treatment for idiopathic epiretinal membrane” Clin Ophthalmol, 5, 147-54 (2011).
  10. Kayama M, Nakazawa T, Thanos A, Morizane Y, Murakami Y, Theodoropoulou S, Abe T, Vavvas D, Miller JW. “Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase” Am J Pathol, 178(3), 1080-1091 (2011).
  11. Ryu M, Nakazawa T, Akagi T, Tanaka T, Watanabe R, Yasuda M, Himori N, Maruyama K, Yamashita T, Abe T , Akashi M, Nishida K. “Suppression of phagocytic cells in retinal disorders using amphiphilic poly(γ-glutamic acid) nanoparticles containing dexamethasone” J Control Release, 151(1), 65-73 (2011).
  12. Fuse N, Mengkegale M, Miyazawa A, Abe T, Nakazawa T, Wakusawa R, Nishida K. “Polymorphisms in ARMS2 (LOC387715) and LOXL1 genes in Japanese with age-related nacular degeneration” Am J Ophthalmol, 151(3), 550-556.e1. (2011).
  13. Kawaguchi Y, Kondo E, Kitamura N, Arakaki K, Tanaka Y, Munekata M, Nagai N, Yasuda K. “In vivo effects of isolated implantation of salmon-derived crosslinked atelocollagen sponge into an osteochondral defect” J Mater Sci Mater Med, 22(2), 397-404 (2011).
  14. Nobuhiro Nagai, Toshiaki Abe “Transscleral Sustained Drug Delivery by Novel Device” BIT’s 1st Annual Symposium of Drug Delivery System (SDDS-2011), Meeting abstract (2011).
  15. Nobuhiro Nagai, Takeaki Kawashima, Hirokazu Kaji, Hideyuki Onami, Norihiro Kumasaka, Matsuhiko Nishizawa, Toshiaki Abe “Evaluation of Ocular Tissue Distribution of Drugs Delivered Transsclerally From A Non-biodegradable Polymeric Capsule Device” Investigative Ophthalmology & Visual Science. 52 (14), 3236-3236 (2011).
  16. Toshiaki Abe, Hideyuki Onami, Nobuhiro Nagai, Norihiro Kumasaka, Ryosuke Wakusawa, Yumi Ishikawa, Shigeki Machida, Hikaru Sonoda, Yasufumi Sato “Suppression of Choroidal Neovascularization By Vasohibin-1 in Monkey Eyes” Investigative Ophthalmology & Visual Science, 52 (14), 4011-4011 (2011).
  17. Yasuyuki Kawaguchi, Eiji Kondo, Nobuto Kitamura, Kazunobu Arakaki, Yasuhito Tanaka, Nobuhiro Nagai, Kazunori Yasuda “In vivo effects of isolated implantation of salmon-derived crosslinked atelocollagen sponge into an osteochondoral defect: Comparison with porcine atelocollagen sponges” 2011 Annual Meeting of the Orthopaedic Research Society, Meeting abstract (2011).
  18. Norihiro Kumasaka, Nobuhiro Nagai, Takeaki Kawashima, Hirokazu Kaji, Hideyuki Onami, Matsuhiko Nishizawa, and Toshiaki Abe. “A novel transscleral drug delivery system for retinal neuroprotection” International Conference of Biomaterials Science (ICBS) 2011, Meeting abstract (2011).


論文2010年

  1. Nobuhiro Nagai, Norihiro Kumasaka, Takeaki Kawashima, Hirokazu Kaji, Matsuhiko Nishizawa, Toshiaki Abe. “Preparation and characterization of collagen microspheres for sustained release of VEGF” Journal of Materials Science: Materials in Medicine, 21(6), 1891-1898 (2010).
  2. Yumi Tokita-Ishikawa, Ryosuke Wakusawa, Toshiaki Abe. “Evaluation of retinal degeneration in P27KIP1 null mouse” Adv Exp Med Biol, 664, 467-71 (2010)
  3. Takeaki Kawashima, Nobuhiro Nagai, Hirokazu Kaji, Norihiro Kumasaka, Hideyuki Onami, Mastuhiko Nishizawa, and Toshiaki Abe. “A polyethylene glycol-based drug delivery capsule device for neuroprotection from retinal diseases” KIST-Tohoku Joint Symposium on Nanobiomedical Engineering, Meeting abstract (2010).
  4. Nobuhiro Nagai, Takeaki Kawashima, Norihiro Kumasaka, Hirokazu Kaji, Hideyuki Onami, Matsuhiko Nishizawa, Toshiaki Abe. “A novel membrane-based drug delivery capsule for retinal neuroprotection” Pacifichem 2010, Meeting abstract (2010).
  5. Toshiaki Abe, Hideyuki Onami, Norihiro Kumasaka, Yumi Tokita-Ishikawa, Hikaru Sonoda, Tomoaki Takakura, Yasuhumi Satoh, Nobuhiro Nagai. “Vasohibin and Retinal Pigment Epithelium” RD2010 XIVth International Symposium in Retinal Degeneration, Meeting abstract (2010).


論文2009年

  1. Takae Saito, Toshiaki Abe, Ryosuke Wakusawa, Hajime Sato, Harunobu Asai, Yumi Tokita-Ishikawa, Kohji Nishida. “TrkB-T1 Receptors on Muller Cells Play Critical Role in Brain-Derived Neurotrophic Factor-Mediated Photoreceptor Protection against Phototoxicity” Current Eye Research, 34(7), 580-8 (2009).
  2. Masahiko Shimura, Kanakko Yasuda, Toru Nakazawa, Toshiaki Abe, Takashi Shiono, Tomohiro Iida, Taiji Sakamoto, Kohji Nishida. “Panretinal photocoagulation induces pro-inflammatory cytokines and macular thickening in high-risk proliferative diabetic retinopathy” Graefe’s Archive for Clinical and Experimental Ophthalmology, 247(12), 1617-1624 (2009).
  3. Hajime Sato, Toshiaki Abe, Ryosuke Wakusawa, Nobuharu Asai, Hiroshi Kunikata. H Ohta. H Sonoda, Yasufumi Sato, Kohji Nishida. “Vitreous levels of vasohibin-1 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy” Diabetologia, 52(2), 359-361 (2009).
  4. Nobuhiro Nagai, Ayumi Hirakawa, Nao Otani, Masanobu Munekata. “Development of tissue-engineered human periodontal ligament constructs with intrinsic angiogenic potential” Cells Tissues Organs, 190(6), 303-312 (2009).
  5. Nobuhiro Nagai, Yasuhide Nakayama, Shogo Nishi, Masanobu Munekata. “Development of novel covered stents using salmon collagen” Journal of Artificial Organs, 12(1), 61-66 (2009).
  6. Nobuhiro Nagai, Hatsumi Kobayashi, Shizuka Katayama, Masanobu Munekata. “Preparation and characterization of collagen from soft-shelled turtle (Pelodiscus sinensis) skin for biomaterial applications” Journal of Biomaterials Science, Polymer Edition, 20(5), 567-576 (2009).
  7. Toshiaki Abe, Yumi Ishikawa, Ryosuke Wakusawa, Hideyuki Onami, Nobuhiro Nagai. “Preparation of neurotrophic factor gene expressing collagen device for retinal diseases” American Society of Gene Therapy 12th Annual Meeting, Vol.17 (Supple. 1), S358-S359 (2009).