Senses consist of a variety of inputs mediated by the cerebral nerve, spinal cord and internal communication network; and it has been well known that that there are sensory inputs other than the commonly used "five senses".
Eye input is believed to account for a considerably large proportion of these senses. In addition, it is believed that the eyes have also had a great influence on diversification of living organisms.
There are various microstructures to maintain the functions of the eyes. These microstructures undergo physiological deterioration due to aging and other causes. It would be impossible to maintain and improve the quality of life without keeping the normal eye function in super aging society.
There are still a number of refractory ophthalmic diseases without treatment methods, especially retinal diseases. Our laboratory is dealing with research on such ophthalmic diseases, especially development of effective treatment methods. In addition to treatment by cell transplantation and gene therapy, we are especially concentrating on our sustained drug-releasing device that enables local release of medications in the eyes in recent years. This device developed by collaborative research with the Graduate School of Engineering is characterized by its extensible property, which allows sustained release of any drug. Therefore, it can be utilized for a variety of diseases, and we are also carrying out joint research with researchers in other fields.
On-line published（Effect of sustained insulin releasing device made of poly(ethyleneglycol) dimethacrylates on retinal function in streptozotocin-induced diabetic rats, Journal of Materials Science: Materials in Medicine）
Ayako Hoshi, Nobuhiro Nagai, Reiko Daigaku, Remi Motoyama, Saaya Saijo, Hirokazu Kaji and Toshiaki Abe
- A clinical trial which is supported by AMED under Grant Number [19lm0203080h0001] starts from March 3, 2020.
Article "diagnosis and treatment of the intractable ophthalmopathy" of Dr. Abe were published in the Miyagi doctor bulletin 884 separate volume 2019.9 issue.
- On-line published（A multilayered sheet-type device capable of sustained drug release and deployment control, Biomedical Microdevices, 21: 60, 2019）
Yuto Sato, Nobuhiro Nagai, Toshiaki Abe and Hirokazu Kaji
- New Publication:（Transscleral sustained ranibizumab delivery using an episcleral implantable device: Suppression of laser-induced choroidal neovascularization in rats, International Journal of Pharmaceutics）
Nobuhiro Nagai, Zhaleh Kashkouli Nezhad, Reuji Daigaku, Saaya Saijo, Yuanhui Song, Keiko Terata, Matsuhiko Nishizawa, Hirokazu Kaji and Toshiaki Abe
- New publication:Development of transscleral sustained drug release device aimed at treatment of intractable retinal disease, Impact,3, 47-49, 2019
Nagai, Nobuhiro; Kaji, Hirokazu; Abe, Toshiaki
- New publication:A drug refillable device for transscleral sustained drug delivery to the retina, European Journal of Pharmaceutics and Biopharmaceutics
Nobuhiro Nagai, Saaya Saijo, Yuanhui Song, Hirokazu Kaji, Toshiaki Abe
- Assistant Professor Nobuhiro Nagai joined Bio Japan 2018.
- Assistant Professor Nagai and Ms. Hoshi(D3） had a presentation at The 34th Annual Meeting of the Japan Society of Drug Delivery System
- Professor Abe appeared in a quarterly magazine of CRIETO
(CRIETO Report vol.18 Spring 2018 P6-7)